February 15th is International Childhood Cancer Day, reminding us that childhood cancer deserves more attention since more than 250,000 children are diagnosed with cancer and about 90,000 children die from cancer every year.

In recent years, the incidence of childhood cancer has been increasing, but children suffering from cancer have not received enough attention from all walks of life. How to make breakthroughs in the field of childhood cancer treatment and find more accurate and effective treatments is a problem that scientists worldwide have been exploring. Recent research on childhood cancer has made some new progress.

Precision medicine of childhood cancer: JAMA Network Open published a research result of the CHU Sainte-Justine TRICEPS team that genomic profiling will help clinical treatment of childhood cancer. Until April 2019, the team had enrolled 84 patients. In 87% of patients, the study identified genomic anomalies that allowed for better patient management. The therapeutic alternatives are personalized because the proposed actions will be different for each patient. The discoveries can lead to a “targeted” therapy because it specifically seeks to block (or bypass) the action of genes that cause cancer progression.

Gene technology for Ewing sarcoma: Ewing sarcoma is a childhood cancer driven by EWS-ETS transcription factor fusion oncoproteins. The majority of tumors express wild-type TP53, and thus, therapies targeting the p53 pathway would benefit most patients. To discover targets specific for TP53 wild-type Ewing sarcoma, scientists used a genome-scale CRISPR-Cas9 screening approach and identified and validated MDM2, MDM4, USP7, and PPM1D as druggable dependencies.

New target for treating childhood cancer: SWI/SNF is a multi-component protein complex that plays an important role in chromatin remodeling. It is also likely an important tumor suppressor, as indicated by the fact that approximately 20% of human cancers carry a mutation in one or more SWI/SNF protein components. This SWI/SNF component protein is mutated in a number of cancers, including malignant rhabdoid tumor (MRT), a highly aggressive, nearly uniformly fatal childhood cancer. William Tansey and his laboratory found that cancers bearing an SNF5 mutation may be susceptible to therapy by MYC inhibition, providing yet another reason why the discovery of clinically viable MYC inhibitors is of utmost importance.

The purpose of modern childhood cancer treatment is not only for the survival rate and the extension of survival time, but also to improve the quality of life. The principle of treatment of pediatric tumors has been raised to the integration of eradication of tumor, functional maintenance and mental health.

For the first two principles, childhood cancer patients are very different from adults, for they are at the stage of growth, thus the treatment plan must take the impact of treatment on the normal development of children into consideration. For example, the widespread use of radiation therapy in adults has been severely limited in childhood cancer treatment due to the risk of skeletal deformities, gonad damage, and intellectual effects in children. In the future, there will be anti-tumor drugs and treatment being more safe, effective, and less toxic, such as biological treatment, gene therapy, differentiation induction therapy to replace traditional chemotherapy and radiotherapy.

For mental health, on the basis of further improvement of tumor eradication and long-term survival, the mental health of children with tumors will be increasingly valued. Psychological problems, including children’s self-experience, psychological effects, concerns about relapses and difficulties in participating in society, should be brought to the attention. Parents should be noticed that organ function and appearance reconstruction are also necessary for those who have suffered growth stagnation, and whose appearance is abnormal due to surgery and radiation therapy.

In short, the childhood cancer treatment is being improved, and under the premise of continuous increase of survival rate, children’s long-term psychological and physical health, as well as functional maintenance must be considered when formulating treatment plans.

Gallstone, varying in sizes is a common health issue reported in hospitals. Generally, cures for treating this health disorder are suggested according to the actual cause of problem. Hardening of cholesterol level in gallbladder is a main cause reported for the formation of stones. It can vary from the size of a grain to the size of a golf ball.

Lifestyle plays a great role in minimizing the risk of gallstones. If you wish to prevent this health issue, then feel free to follow a healthy lifestyle with daily diet and regular exercises. Regular exercises in combination with healthy diet can reduce the probability of gallstone formation. As per studies, certain herbal remedies are found to be very good to flush out gallstones from body. In this article, we are going to see natural gallbladder stones dissolver and remover supplements pills in detail.

Consider a combination of lime juice, honey and olive oil. If you are a person suffering from gallstone complaints, feel free to include a combination of the above specified ingredients in daily diet. For the best result, try to intake the herbal combination early in the morning prior to breakfast. It can stimulate digestion and prevent the occurrence of health issues due to indigestion.

Blackseed oil is another safe cure for treating gallstones. People under any age group can use this particular cure in their daily diet. Lecithin is a natural cure for treating many health issues due to cholesterol accumulation. It acts on HDL cholesterol level and prevents the risk of gallstone formation. Today, lecithin products can be easily availed from online stores.

Similar to lecithin, turmeric is another safe cure for treating gallstones. Curcumin, an active ingredient in turmeric is mainly responsible for this health issue. It acts as an anti-inflammatory agent and treats a wide range of gall bladder issues related to inflammations. Today, turmeric is added as an active ingredient for the preparation of many herbal products that treat gallstones. You can even get turmeric powder in the form of capsules from market.

Studies say that adding even a half tablespoon turmeric powder in diet can reduce the risk of gallstone formation up to 80%. If you are in search of a safe cure for treating gallstones, feel free to include turmeric powder in your daily food recipes. Is there any fruit juice that can cure gallstone formation? This is a common question heard many people.

As per studies, including fruit juices like beetroot juice, pear juice and apple juice in daily diet are found to be very good to improve liver health. It cleanses liver and prevents health risk due to gallstones naturally. Today, you can find a wonderful range of herbal products in online stores boasting cure from gallstone formation. At times, you may not be able to pick up the right product for gallstone from market. Here, you can seek the help of nutritionists available online.

Today, KidClear is one of the best recommended herbal cures for gallstones. To attain the best result, try to follow a healthy lifestyle with daily diet and regular exercises. Kid Clear, enriched with potential herbs serves as the best cure for toxin accumulation and gallstone formation.

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In general, fairness is considered as the prettiness and this is why most of us wish to maintain or get a fair complexion. To improve skin health, it is better to rely on safe methods. The reason is that when inappropriate cosmetics are used, there are chances of ill-effects on the skin. Rather than bringing fairness and skin healthy, an inappropriate cosmetic can ruin the natural beauty. This is why it is better to rely on natural cure for pimples and acne. Besides providing relief to different skin issues, the safe product that is chosen should also improve the complexion and glow in the face. This is where Golden Glow capsules get into the picture.

What can Golden Glow capsules do to your kin?

To improve skin health, these capsules can be the most effective and the safest remedy ever. Besides improving skin health, these capsules will also improve complexion and also a natural glow. In general, beauticians say that the level of melanin produced in the skin decides the fairness of an individual. For instance, dark people will have more melanin production in their skin as against individuals with fair skin complexion. Melanin is naturally produced by the body to counter the effects of radiation of the Sun. So, without any doubt melanin is an importance substance without which our skin will not stay healthy.

Here, the natural cure for pimples and acne called Golden Glow capsules will help with maintaining the right level of melanin production. This, in turn, will improve both the skin health and its fairness. Some of us have a dark skin complexion right from childhood days and this is something decided by our genes. Even, if you have such a dark complexion due to genes, these capsules will help in achieving fairness. This can be done by the capsules by bringing down the amount of melanin production in your skin.

Spending longer hours outdoors:

Some of us will have to remain outdoors for long either for our profession or for other reasons. This will lead to skin blemishes and these individuals develop dark spots. This is because of the over-deposition of the melanin at a single place. But, to improve skin health in these individuals, Golden Glow capsules will diffuse the deposition of melanin and will provide whiter and even skin tone. Many people say that acne and pimples are the biggest issues that affect their natural beauty. But, Golden Glow capsules can bring natural cure for pimples and acne. Golden Glow capsules will provide nourishment to the skin from inside and will keep the skin cells healthy to make sure that natural moisture is maintained.

Effective ingredients:

To improve skin health and also to provide a natural cure for pimples and acne, Golden Glow capsules contain a number of healthy and effective ingredients. Some will address skin infections, while some will improve fairness. Also, some ingredients will ensure healthy melanin production. All the 22 herbal ingredients in these capsules will jointly bring excellent improvement in the skin health.

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